Medications For Bacterial Skin Infections

Cellulitis

Cellulitis is a painful, erythematous infection of the dermis and subcutaneous tissues that is characterized by warmth, edema, and advancing borders.

Cellulitis commonly occurs near breaks in the skin, such as surgical wounds, trauma, tinea infections.

 healthy adults, isolation of an etiologic agent is difficult and unrewarding. If the patient has diabetes, an immunocompromising disease, or persistent inflammation, blood cultures or aspiration (some physicians inject sterile nonpreserved saline before aspiration) of the area of maximal inflammation may be useful.

For infection in patients without diabetes, empiric treatment with a penicillinase-resistant penicillin, first-generation cephalosporin, amoxicillin-clavulanate (Augmentin), macrolide, or fluoroquinolone (adults only) is appropriate.

A parenteral second- or third-generation cephalosporin (with or without an aminoglycoside) should be considered in patients who have diabetes, immunocompromised patients, those with unresponsive infections, or in young children.

Erysipelas

Erysipelas, also known as St. Anthony's fire, usually presents as an intensely erythematous infection with clearly demarcated raised margins, and often with associated lymphatic streaking. Common sites are the legs and face. Most cases do not have an inciting wound or skin lesion and are preceded by influenza-like symptoms. The incidence of erysipelas is rising, especially in young children, the elderly, persons with diabetes, alcoholic persons, and patients with compromised immune systems or lymphedema.

Erysipelas is caused almost exclusively by beta-hemolytic streptococcus and thus can be treated with standard dosages of oral or intravenous penicillin. However, most physicians treat this infection the same as cellulitis, which is outlined earlier. Adjunctive treatment and complications are the same as for cellulitis.

Impetigo

Impetigo is most commonly seen in children aged two to five years and is classified as bullous or nonbullous.
 The nonbullous type predominates and presents with an erosion (sore), cluster of erosions, or small vesicles or pustules that have an adherent or oozing honey-yellow crust. The predilection for the very young can be remembered by the common lay misnomer, “infant tigo.” Impetigo usually appears in areas where there is a break in the skin, such as a wound, herpes simplex infection, or maceration associated with angular cheilitis , but Staphylococcus aureus can directly invade the skin and cause a de novo infection.

The bullous form of impetigo presents as a large thin-walled bulla (2 to 5 cm) containing serous yellow fluid. It often ruptures leaving a complete or partially denuded area with a ring or arc of remaining bulla.

More than one area may be involved and a mix of bullous and nonbullous findings can exist. Nonbullous impetigo was previously thought to be a group A streptococcal process and bullous impetigo was primarily thought to be caused by S. aureus. Studies now indicate that both forms of impetigo are primarily caused by S. aureus with Streptococcus usually being involved in the nonbullous form. If the infection is a toxin-producing, phage group II, type 71 Staphylococcus (the same toxin seen in Staphylococcus scalded skin syndrome, a medical emergency where large sheets of the upper epidermis slough off), large bullae will form as the toxin produces intradermal cleavage.Otherwise, smaller bullae develop and the honey-crusted lesions predominate.


topical mupirocin (Bactroban) ointment is as effective as oral erythromycin in treating impetigo.

 However, because the lesions of bullous impetigo can be large and both forms of impetigo can have satellite lesions, an oral antibiotic with activity against S. aureus and group A beta-hemolytic streptococcal infection is warranted in nonlocalized cases. 

  Because of developing resistance, erythromycin is no longer the drug of choice. Azithromycin (Zithromax) for five days and cephalexin (Keflex) for 10 days have been shown to be effective and well-tolerated. Dicloxacillin (Pathocil), oxacillin (Prostaphlin), first-generation cephalosporins, or amoxicillin-clavulanate are also acceptable alternatives.5 Broad-spectrum fluoroquinolones have also been shown to be effective.

Folliculitis

Hair follicles can become inflamed by physical injury, chemical irritation, or infection that leads to folliculitis.

Classification is by the depth of involvement of the hair follicle. The most common form is superficial folliculitis that manifests as a tender or painless pustule that heals without scarring.24 The hair shaft will frequently be seen in the center of the pustule. Multiple or single lesions can appear on any skin bearing hair including the head, neck, trunk, buttocks, and extremities.
 Associated systemic symptoms or fever rarely exist. S. aureus is the most likely pathogen; however, commensal organisms such as yeast and fungi occasionally appear, especially in immunocompromised patients. These lesions typically resolve spontaneously. Topical therapy with erythromycin, clindamycin, mupirocin, or benzoyl peroxide can be administered to accelerate the healing process.

taphylococci will occasionally invade the deeper portion of the follicle, causing swelling and erythema with or without a pustule at the skin surface. These lesions are painful and may scar. This inflammation of the entire follicle or the deeper portion of the hair follicle (isthmus and below) is called deep folliculitis. Oral antibiotics are usually used in the treatment and include first-generation cephalosporins, penicillinase-resistant penicillins, macrolides, and fluoroquinolones.

Gram-negative folliculitis usually involves the face and affects patients with a history of long-term antibiotic therapy for acne. Pathogens include Klebsiella, Enterobacter, and Proteus species. It can be treated as severe acne with isotretinoin (Accutane), but use of isotretinoin is associated with major side effects, including birth defects.

“Hot tub” folliculitis is caused by Pseudomonas aeruginosa contamination of under-treated water in a hot tub or whirlpool. Multiple pustular or papular perifollicular lesions appear on the trunk and sometimes extremities within six to 72 hours after exposure, and mild fever and malaise may occur. Lesions in the immunocompetent patient typically resolve spontaneously within a period of seven to 10 days. Treatment is directed at prevention by appropriately cleaning the whirlpool or hot tub and maintaining appropriate chlorine levels (bromine and copper solutions are less common alternatives) in the water.

Furuncles and Carbuncles

Furuncles and carbuncles occur as a follicular infection progresses deeper and extends out from the follicle. Commonly known as an abscess or boil, a furuncle is a tender, erythematous, firm or fluctuant mass of walled-off purulent material, arising from the hair follicle. 

These lesions may occur anywhere on the body, but have a predilection for areas exposed to friction. Furuncles rarely appear before puberty. The pathogen is usually S. aureus. Typically, the furuncle will develop into a fluctuant mass and eventually open to the skin surface, allowing the purulent contents to drain, either spontaneously or following incision of the furuncle.

Carbuncles are an aggregate of infected hair follicles that form broad, swollen, erythematous, deep, and painful masses that usually open and drain through multiple tracts. Constitutional symptoms, including fever and malaise, are commonly associated with these lesions but are rarely found with furuncles. With both of these lesions, gentle incision and drainage is indicated when lesions “point” (fluctuant or boggy with a thin shiny appearance of the overlying skin); caution should be taken to not incise deeper than the pseudo capsule that has been built at the site of infection. 

Loculations should be broken with a hemostat. The wound may be packed (usually with iodoform gauze) to encourage further drainage. In severe cases, parenteral antibiotics such as cloxacillin (Tegopen), or a first-generation cephalosporin such as cefazolin (Ancef), are required. The physician should be aware of the potential for gas-containing abscesses or necrotizing fasciitis, which require immediate surgical debridement.