Therapy addressing specific symptoms is the mainstay for most upper respiratory infections (URIs). Most URIs are self-limited viral infections that resolve without prescription drugs. Recognizing viral and bacterial diseases for which specific therapy is available is important. Awareness of local trends in prevalent organisms and local resistance patterns is key. Antibacterial therapy is appropriate for patients with any of the following: Group A streptococcal pharyngitis Bacterial sinusitis Epiglottitis Pertussis Diphtheria Antibiotics used in group A streptococcal infection are as follows: Penicillin VK (Penicillin V) Amoxicillin (Amoxil, Moxatag, Trimox) Penicillin G benzathine (Bicillin LA, Permapen) Cefadroxil (Duricef) Erythromycin (E.E.S., Erythrocin, E-Mycin, Eryc) Amoxicillin and clavulanate (Augmentin, Augmentin XR) Cefaclor (Ceclor) Cefuroxime (Ceftin) Ceftriaxone (Rocephin) Azithromycin (Zithromax) Antibiotics used i...